Bladder: Urothelial carcinomas
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چکیده
منابع مشابه
IMP3 expression in urothelial carcinomas of the urinary bladder.
OBJECTIVE Superficial tumors including Ta, Tis, and T1 make up 75% of urothelial carcinomas of the bladder. While the behavior of these superficial urothelial cancers is relatively benign, invasive tumors have a significant mortality rate. However, Ta and T1 tumors might display different biological behavior. There is therefore a great need for biomarkers that can accurately distinguish the beh...
متن کاملPIK3CA Mutational Analysis in Formalin-Fixed, Paraffin-Embedded Archival Tissues of Urothelial Carcinoma of Urinary Bladder
Objective: Urothelial carcinoma of the urinary bladder is the fourth most common cancer in males in the United States. In addition to mutations in FGFR3, TP53, AKT1, TSC1, and PTEN genes, mutations in PIK3CA have been also described in urothelial carcinomas, preferentially in low-grade tumors. Mutations in PIK3CA also has been shown to have implications for prognosis, surveillance and therapeut...
متن کاملUpper Tract Urothelial Carcinomas in Patients with Chronic Kidney Disease: Relationship with Diagnostic Challenge
Chronic kidney disease and upper tract urothelial carcinomas display a bidirectional relationship. Review of the literature indicates that early diagnosis and correct localization of upper tract urothelial carcinomas in dialysis patients and kidney transplant recipients are important but problematic. Urine cytology and cystoscopy have limited sensitivity for the diagnosis of upper tract urothel...
متن کاملCD10 expression in urothelial bladder carcinomas: staining patterns and relationship with pathologic parameters*
Aim: CD10 is a cell surface metalloprotease that inactivates various bioactive neuropeptides. CD10 has been suggested as a useful prognostic marker for urothelial carcinoma, but there are only a few studies of CD10 in urothelial tumors and they have shown varying results. The aims of this study were to investigate the expression of CD10 in urothelial bladder carcinomas and to clarify its associ...
متن کاملUrothelial carcinoma: Recurrence and risk factors.
Urothelial carcinomas are malignant tumors that arise from the urothelial epithelium and may involve the lower and upper urinary tract. They are characterized by multiple, multifocal recurrences throughout the genitourinary tract. Bladder tumors account for 90-95% of urothelial carcinomas and are the most common malignancies of the urinary tract. Upper urinary tract urothelial carcinomas (UTUC)...
متن کاملki-67, p53, Bcl-2 and Bax Expression in urothelial Carcinomas of urinary Bladder Mesanenin Ürotelyal karsinomlarında ki-67, p53, Bcl-2 ve Bax Ekspresyonu
Objective: The most important predictive parameter for the biological behavior of urothelial carcinomas except depth of invasion is the histological grade of the tumor. However, crucial discordances arise between pathologists because of subjectivity in histological grading schemes and these discordances cause difficulties especially in lowgrade tumors. The number of studies aiming to predict th...
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